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Side Effects of Enacard

| Updated September 26, 2017

Enacard is an angiotensin-converting-enzyme (ACE) inhibitor that is used as a vasodilator to treat heart failure, cardiomyopathy and high blood pressure. It is currently only FDA-approved for use in dogs, but many veterinarians use it to treat cats as well. The standard dose in dogs is 0.25 milligrams per pound (mg/lb.), administered daily. For cats, the dose hovers around 0.1 to 0.25 mg/lb. As with any drug, there do exist side effects, some more serious than others.

Low Blood Pressure

Since Enacard is used to combat high blood pressure, it has the capacity to relax blood vessels to such an extent that it can cause low blood pressure. This can result in a sudden onset of weakness or lethargy in the animal. A veterinarian should be contacted in the event of low blood pressure, because it can also be a symptom of an overdose.

Loss of Appetite

The animal might be prone to a loss of appetite, which is only a major cause for concern if he or she refuses to eat any food/drink whatsoever. If this be the case, it’s best to seek immediate veterinary attention.


If the vomiting appears to be excessive to the point that it is causing pain to the animal, notify the attending veterinarian. However, a single bout of vomiting is not cause for concern, as it is a common occurrence whenever a pet is given a new medication.


If diarrhea persists for longer than one or two days, veterinary intervention is recommended. Like vomiting, diarrhea can sometimes occur as the pet's body adjusts to a new medication.

Kidney Problems

Changes in urination might be a sign of a greater kidney problem. Enacard has the potential to affect blood supply to the kidneys, which can lead to kidney failure. This is more likely to happen as a result of an overdose. If the pet appears to have difficulty urinating, or seems at all constipated or in pain, a veterinarian should be contacted immediately, as this could be a sign of kidney problems.


Side effects are more likely to surface if Enacard is administered with other drugs, like diuretics or those that relax blood vessels. It should also not be given to animals that are allergic to ACE inhibitors, or those that are pregnant or nursing. Store the medication in a tightly closed container, at room temperature and away from excess light and moisture.